This is a remake of the original Broken Sword game, which will be released on the Wii and DS, and is due out in March.
The game will include new scenes (the original opening scene with George in the Cafe will now take place a little later in the game,) and should explain certain events in more detail.
So far it doesn't seem like there are any differences between the Wii and DS versions, except that the Wii version will include voice acting (Rolf Saxon will again do the voice of George for the new scenes, and the original voice actor for Nico will also be returning for the new scenes.)
The DS version, however, will not have voice acting.
Q&A with Charles Cecil (includes a couple of screenshots):
http://uk.wii.ign.com/articles/949/949584p1.html
Box art: